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LRI Publications

2025
  • Meca-Laguna, G., Admasu, T. D., Shankar, A., Barkovskaya, A., Collibee, I., Krakauer, A., Tran, T., Rae, M., & Sharma, A. (May 9, 2025). γδ T Cells Target and Ablate Senescent Cells in Aging and Alleviate Pulmonary Fibrosis. bioRxiv (Cold Spring Harbor Laboratory). https://doi.org/10.1101/2025.05.05.652251
  • Barkovskaya, A., Kim, K., Shankar, A., Meca-Laguna, G., Rae, M., Saux, C. J. L., & Sharma, A. (March 19, 2025). Inhibition of PIKfyve kinase induces senescent cell death by suppressing lysosomal exocytosis and leads to improved outcomes in a mouse model of idiopathic pulmonary fibrosis. bioRxiv (Cold Spring Harbor Laboratory). https://doi.org/10.1101/2025.03.19.644224
  • Mecalaguna, G., Qiu, M., Barkovskaya, A., Shankar, A., Rae, M., & Sharma, A. (March 11, 2025). Cell-Surface LAMP1 is a Senescence Marker in Aging and Idiopathic Pulmonary Fibrosis. bioRxiv (Cold Spring Harbor Laboratory). https://doi.org/10.1101/2025.03.04.640878
  • Frost, O. G., Barkovskaya, A., Rae, M., Atzori, M., Rebbaa, A., & Sharma, A. (Feb 25, 2025). Analysis of the current state of frailty indexes and their implementation for aging intervention studies. bioRxiv (Cold Spring Harbor Laboratory). https://doi.org/10.1101/2025.02.24.639506
  • Barkovskaya, A., Brauning, A., Chamoli, M., Rane, A., Andersen, J. K., & Sharma, A. (Jan 8, 2025). Mitigating Proinflammatory SASP and DAMP with Urolithin A: A Novel Senomorphic Strategy. bioRxiv (Cold Spring Harbor Laboratory). https://doi.org/10.1101/2025.01.07.631588
  • Begelman DV, Dixit B, Truong C, King CD, Watson MA, Schilling B, Brand MD, Boominathan A Exogenous expression of ATP8, a mitochondrial encoded protein, from the nucleus in vivo. Mol Ther Methods Clin Dev. 2024 Nov 6;32(4):101372. doi: 10.1016/j.omtm.2024.101372. eCollection 2024 Dec 12.PMID: 39659757.

  • Frost OG, Ramkilawan P, Rebbaa A, Stolzing A. A systematic review of lifespan studies in rodents using stem cell transplantations. Ageing Res Rev. 2024 Jun;97:102295. doi: 10.1016/j.arr.2024.102295. Epub 2024 Apr 6. PubMed: 38588866.

  • Admasu TD, Kim K, Rae M, Avelar R, Gonciarz RL, Rebbaa A, Pedro de Magalhães J, Renslo AR, Stolzing A, Sharma A. Selective ablation of primary and paracrine senescent cells by targeting iron dyshomeostasis. Cell Rep. 2023 Feb 6;42(2):112058. doi: 10.1016/j.celrep.2023.112058. PubMed: 36753419.
  • Brauning A, Rae M, Zhu G, Fulton E, Admasu TD, Stolzing A, Sharma A. Aging of the Immune System: Focus on Natural Killer Cells Phenotype and Functions. Cells. 2022 Mar 17;11(6):1017. doi: 10.3390/cells11061017. PMID: 35326467; PMCID: PMC8947539.
  • Kim K, Admasu TD, Stolzing A, Sharma A. Enhanced co-culture and enrichment of human natural killer cells for the selective clearance of senescent cells. Aging (Albany NY). 2022 Mar 4;14(undefined). doi: 10.18632/aging.203931. Online ahead of print. PubMed: 35245208
  • Saravanan S, Lewis CJ, Dixit B, O’Connor MS, Stolzing A, Boominathan A. The Mitochondrial Genome in Aging and Disease and the Future of Mitochondrial Therapeutics. Biomedicines. 2022 Feb 18;10(2):490. doi: 10.3390/biomedicines10020490. PubMed: 35203698

  • Admasu TD, Barardo D, Ng LF, Batchu KC, Cazenave-Gassiot A, Wenk MR, Gruber J. A small-molecule Psora-4 acts as a caloric restriction mimetic to promote longevity in C. elegans. Geroscience. 2022 Apr;44(2):1029-1046. doi: 10.1007/s11357-021-00374-6. Epub 2021 May 14. PubMed: 33988831. PMCID: PMC9135947.

  • Dixit B, Vanhoozer S, Anti NA, O’Connor MS, Boominathan A. Rapid enrichment of mitochondria from mammalian cell cultures using digitonin. MethodsX 2021;8:101197. Document via external site.
  • Olgasi C, Borsotti C, Merlin S, Bergmann T, Bittorf P, Adewoye AB, Wragg N, Patterson K, Calabria A, Benedicenti F, Cucci A, Borchiellini A, Pollio B, Montini E, Mazzuca DM, Zierau M, Stolzing A, Toleikis PM, Braspenning J, Follenzi A. Efficient and safe correction of hemophilia A by lentiviral vector-transduced BOECs in an implantable device. Mol Ther Methods Clin Dev. 2021 Nov 3;23:551-566. doi: 10.1016/j.omtm.2021.10.015. eCollection 2021 Dec 10. PubMed: 34853801
  • Anderson AM, Kirtadze T, Malanga M, Dinh D, Barnes C, Campo A, Clemens DM, Garcia-Fandiño R, Piñeiro Á, O’Connor MS. Cyclodextrin dimers: A versatile approach to optimizing encapsulation and their application to therapeutic extraction of toxic oxysterols. Int J Pharm. 2021 Sep 5;606:120522. PubMed: 33839224
  • Admasu TD, Rae M, Stolzing A. Dissecting primary and secondary senescence to enable new senotherapeutic strategies. Ageing Res Rev. 2021 Sep;70:101412. doi: 10.1016/j.arr.2021.101412. Epub 2021 Jul 21. PubMed: 34302996
  • Mkrtchyan GV, Abdelmohsen K, Andreux P, Bagdonaite I, Barzilai N, Brunak S, Cabreiro F, de Cabo R, Campisi J, Cuervo AM, Demaria M, Ewald CY, Fang EF, Faragher R, Ferrucci L, Freund A, Silva-García CG, Georgievskaya A, Gladyshev VN, Glass DJ, Gorbunova V, de Grey A, He WW, Hoeijmakers J, Hoffmann E, Horvath S, Houtkooper RH, Jensen MK, Jensen MB, Kane A, Kassem M, de Keizer P, Kennedy B, Karsenty G, Lamming DW, Lee KF, MacAulay N, Mamoshina P, Mellon J, Molenaars M, Moskalev A, Mund A, Niedernhofer L, Osborne B, Pak HH, Parkhitko A, Raimundo N, Rando TA, Rasmussen LJ, Reis C, Riedel CG, Franco-Romero A, Schumacher B, Sinclair DA, Suh Y, Taub PR, Toiber D, Treebak JT, Valenzano DR, Verdin E, Vijg J, Young S, Zhang L, Bakula D, Zhavoronkov A, Scheibye-Knudsen M. ARDD 2020: from aging mechanisms to interventions. Aging (Albany NY). 2020 Dec 30;12(24):24484-24503. PubMed: 33378272.
  • Wragg NM, Tampakis D, Stolzing A. Cryopreservation of Mesenchymal Stem Cells Using Medical Grade Ice Nucleation Inducer. Int J Mol Sci. 2020 Nov 13;21(22):8579. PubMed: 33203028.

  • Sharma A, Akagi K, Pattavina B, Wilson KA, Nelson C, Watson M, Maksoud E, Harata A, Ortega M, Brem RB, Kapahi P. Musashi expression in intestinal stem cells attenuates radiation-induced decline in intestinal permeability and survival in Drosophila. Sci Rep. 2020 Nov 5;10(1):19080. doi: 10.1038/s41598-020-75867-z. PubMed: 33154387. PMCID: PMC7644626.

  • Kale A, Sharma A, Stolzing A, Desprez PY, Campisi J. Role of immune cells in the removal of deleterious senescent cells. Immun Ageing 2020 Jun 3;17:16. PubMed: 32518575.
  • Lewis CJ, Dixit B, Batiuk E, Hall CJ, O’Connor MS, Boominathan A. Codon optimization is an essential parameter for the efficient allotopic expression of mtDNA genes. Redox Biol. 2020 Feb;30:101429. PMID: 31981894.
  • Anderson A, Campo A, Fulton E, Corwin A, Jerome WG 3rd, O’Connor MS. 7-Ketocholesterol in disease and aging. Redox Biol. 2020 Jan;29:101380. PMID: 31926618.
  • Bakula D, Ablasser A, Aguzzi A, Antebi A, Barzilai N, Bittner MI, Jensen MB, Calkhoven CF, Chen D, Grey ADNJ, Feige JN, Georgievskaya A, Gladyshev VN, Golato T, Gudkov AV, Hoppe T, Kaeberlein M, Katajisto P, Kennedy BK, Lal U, Martin-Villalba A, Moskalev AA, Ozerov I, Petr MA, Reason, Rubinsztein DC, Tyshkovskiy A, Vanhaelen Q, Zhavoronkov A, Scheibye-Knudsen M. Latest advances in aging research and drug discovery. Aging (Albany NY). 2019 Nov 21;11(22):9971-9981. doi: 10.18632/aging.102487. Epub 2019 Nov 21. PubMed: 31770722. PMCID: PMC6914421.
  • West MD, Sternberg H, Labat I, Janus J, Chapman KB, Malik NN, de Grey AD, Larocca D. Toward a unified theory of aging and regeneration. Regen Med. 2019 Sep;14(9):867-886. PMID: 31455183.
  • West MD, Chang CF, Larocca D, Li J, Jiang J, Sim P, Labat I, Chapman KB, Wong KE, Nicoll J, Van Kanegan MJ, de Grey ADNJ, Nasonkin IO, Stahl A, Sternberg H. Clonal derivation of white and brown adipocyte progenitor cell lines from human pluripotent stem cells. Stem Cell Res Ther. 2019 Jan 8;10(1):7. PMID: 30616682.
  • Boominathan A, Vanhoozer S, Basisty N, Powers K, Crampton AL, Wang X, Friedricks N, Schilling B, Brand MD, O’Connor MS. Stable nuclear expression of ATP8 and ATP6 genes rescues a mtDNA Complex V null mutant. Nucleic Acids Res. 2016 Sep 4. PubMed: 27596602.
  • Luo D, Smith JA, Meadows NA, Manescu K, Bure K, Davies B, Horne R, DiGiusto DL, Brindley DA. A Quantitative Assessment of Factors Affecting the Technological Development and Adoption of Companion Diagnostics. Front. Genet. 6:357. Read on external site.
  • Rae MJ. SENS Foundation: Accelerating Progress Toward Biomedical Rejuvenation. In: Fahy GM, West M, Coles LS, Harris SB (eds). The Future of Aging: Pathways to Human Life Extension, Chapter: SENS Foundation: Accelerating Progress Toward Biomedical Rejuvenation. 2010; Springer Verlag, New York, pp. 806–826. Read on external site.
  • Rae MJ, Butler RN, Campisi J, de Grey ADNJ, Finch CE, Gough M, Martin GM, Vijg J, Perrott KM, Logan BJ. The Demographic and Biomedical Case for Late-Life Interventions in Aging. Sci Transl Med. 2010 Jul 14;2(40):40cm21. PubMed: 20630854.

LRI Supported Publications

2025
  • Mishra SK, Yasir M, Kuppusamy R, Wong EHH, Hui A, Sørensen K, Lin JS, Jenssen H, Barron AE, Willcox M. Antimicrobial activity of peptoids against Metallo-β-lactamase-producing Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and other WHO priority pathogens, including Candida auris. J Appl Microbiol. 2025 Mar 3;136(3):lxaf031. doi: 10.1093/jambio/lxaf031. PubMed: 39933590. PMCID: PMC11879280.
  • Wardell SJT, Yung DBY, Nielsen JE, Lamichhane R, Sørensen K, Molchanova N, Herlan C, Lin JS, Bräse S, Wise LM, Barron AE, Pletzer D. A biofilm-targeting lipo-peptoid to treat Pseudomonas aeruginosa and Staphylococcus aureus co-infections. Biofilm. 2025 Mar 12;9:100272. doi: 10.1016/j.bioflm.2025.100272. eCollection 2025 Jun. PubMed: 40248507. PMCID: PMC12005307.
  • Mogck BA, Jezak ST, Wiley CD. Mitochondria-Targeted Catalase Does Not Suppress Development of Cellular Senescence during Aging. Biomedicines. 2024 Feb 10;12(2):414. doi: 10.3390/biomedicines12020414. PMID: 38398016; PMCID: PMC10886841.

  • Rossignoli F, Hoffman D, Atif E, Shah K. Developing and characterizing a two-layered safety switch for cell therapies. Cancer Biol Ther. 2023 Dec 31;24(1):2232146. doi: 10.1080/15384047.2023.2232146. Erratum in: Cancer Biol Ther. 2024 Dec 31;25(1):2392996. doi: 10.1080/15384047.2024.2392996. PMID: 37439774; PMCID: PMC10348026.

  • Ballesteros-Álvarez J, Nguyen W, Sivapatham R, Rane A, Andersen JK. Urolithin A reduces amyloid-beta load and improves cognitive deficits uncorrelated with plaque burden in a mouse model of Alzheimer’s disease. Geroscience. 2023 Apr;45(2):1095-1113. doi: 10.1007/s11357-022-00708-y. Epub 2022 Dec 28. PMID: 36576642; PMCID: PMC9886708.

  • Liao CY, Kummert OMP, Bair AM, Alavi N, Alavi J, Miller DM, Bagga I, Schempf AM, Hsu YM, Woods BD, Brown Mayfield SM, Mitchell AN, Tannady G, Talbot AR, Dueck AM, Barrera Ovando R, Parker HD, Wang J, Schoeneweis JK, Kennedy BK. The Autophagy Inducer Spermidine Protects Against Metabolic Dysfunction During Overnutrition. J Gerontol A Biol Sci Med Sci. 2021 Sep 13;76(10):1714-1725. doi: 10.1093/gerona/glab145. PMID: 34060628; PMCID: PMC8436989.

  • Covarrubias AJ, Kale A, Perrone R, Lopez-Dominguez JA, Pisco AO, Kasler HG, Schmidt MS, Heckenbach I, Kwok R, Wiley CD, Wong HS, Gibbs E, Iyer SS, Basisty N, Wu Q, Kim IJ, Silva E, Vitangcol K, Shin KO, Lee YM, Riley R, Ben-Sahra I, Ott M, Schilling B, Scheibye-Knudsen M, Ishihara K, Quake SR, Newman J, Brenner C, Campisi J, Verdin E. Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages. Nat Metab. 2020 Nov;2(11):1265-1283. PubMed: 33199924.
  • Streeter MD, Rowan S, Ray J, McDonald DM, Volkin J, Clark J, Taylor A, Spiegel DA. Generation and Characterization of Anti-Glucosepane Antibodies Enabling Direct Detection of Glucosepane in Retinal Tissue. ACS Chem Biol. 2020 Sep 25; acschembio.0c00093. PubMed: 32975399.
  • Jiang L, Wang M, Lin S, Jian R, Li X, Chan J, Dong G, Fang H, Robinson AE; GTEx Consortium; Snyder MP. A Quantitative Proteome Map of the Human Body. Cell. 2020 Oct 1;183(1):269-283.e19. doi: 10.1016/j.cell.2020.08.036. Epub 2020 Sep 10. PMID: 32916130; PMCID: PMC7575058.
  • Frasca A, Xue Y, Kossar AP, Keeney S, Rock C, Zakharchenko A, Streeter M, Gorman RC, Grau JB, George I, Bavaria JE, Krieger A, Spiegel DA, Levy RJ, Ferrari G. Glycation and Serum Albumin Infiltration Contribute to the Structural Degeneration of Bioprosthetic Heart Valves. JACC Basic Transl Sci. 2020 Aug 5;5(8):755-766. PubMed: 32875167.
  • Stammers M, Niewczas IS, Segonds-Pichon A, Clark J. Mechanical Stretching Changes Cross-Linking and Glycation Levels in the Collagen of Mouse Tail Tendon. J Biol Chem. 2020 Jul 31; 295(31):10572-10580. PubMed: 32546479.
  • Stammers M, Ivanova IM, Niewczas IS, Segonds-Pichon A, Streeter M, Spiegel DA, Clark J. Age-related changes in the physical properties, cross-linking, and glycation of collagen from mouse tail tendon. J Biol Chem. 2020 Jul 31;295(31):10562-10571. PubMed: 32381510.
  • Walton CC, Begelman D, Nguyen W, Andersen JK. Senescence as an Amyloid Cascade: The Amyloid Senescence Hypothesis. Front Cell Neurosci. 2020 May 19;14:129. PubMed: 32508595.
  • Basisty N, Kale A, Patel S, Campisi J, Schilling B. The power of proteomics to monitor senescence-associated secretory phenotypes and beyond: toward clinical applications. Expert Rev Proteomics. 2020 Apr;17(4):297-308. PubMed: 32425074.
  • Bansode S, Bashtanova U, Li R, Clark J, Müller KH, Puszkarska A, Goldberga I, Chetwood HH, Reid DG, Colwell LJ, Skepper JN, Shanahan CM, Schitter G, Mesquida P, Duer MJ. Glycation changes molecular organization and charge distribution in type I collagen fibrils. Sci Rep. 2020 Feb 25;10(1):3397. PubMed: 32099005.
  • Gaffney DO, Jennings EQ, Anderson CC, Marentette JO, Shi T, Schou Oxvig AM, Streeter MD, Johannsen M, Spiegel DA, Chapman E, Roede JR, Galligan JJ. Non-enzymatic Lysine Lactoylation of Glycolytic Enzymes. Cell Chem Biol. 2020 Feb 20;27(2):206-213.e6. PMID: 31767537.

  • Kavari SL, Shah K. Engineered stem cells targeting multiple cell surface receptors in tumors. Stem Cells. 2020 Jan;38(1):34-44. doi: 10.1002/stem.3069. Epub 2019 Aug 21. PMID: 31381835; PMCID: PMC6981034.

  • Basisty N, Kale A, Jeon OH, Kuehnemann C, Payne T, Rao C, Holtz A, Shah S, Sharma V, Ferrucci L, Campisi J, Schilling B. A proteomic atlas of senescence-associated secretomes for aging biomarker development. PLoS Biol. 2020 Jan 16;18(1):e3000599. PMID: 31945054.
  • Planque SA, Massey RJ, Paul S. Catalytic antibody (catabody) platform for age-associated amyloid disease: From Heisenberg’s uncertainty principle to the verge of medical interventions. Mech Ageing Dev. 2020 Jan;185:111188. PMID: 31783036.
  • Sabbasani VR, Wang KP, Streeter MD, Spiegel DA. One-Step Synthesis of 2,5-Diaminoimidazoles and Total Synthesis of Methylglyoxal-Derived Imidazolium Crosslink (MODIC). Angew Chem Int Ed Engl. 2019 Dec 19;58(52):18913-18917. PMID: 31713976.
  • Furman D, Campisi J, Verdin E, Carrera-Bastos P, Targ S, Franceschi C, Ferrucci L, Gilroy DW, Fasano A, Miller GW, Miller AH, Mantovani A, Weyand CM, Barzilai N, Goronzy JJ, Rando TA, Effros RB, Lucia A, Kleinstreuer N, Slavich GM. Chronic inflammation in the etiology of disease across the life span. Nat Med. 2019 Dec;25(12):1822-1832. PMID: 31806905.
  • Kim NY, Goddard TN, Sohn S, Spiegel DA, Crawford JM. Biocatalytic Reversal of Advanced Glycation End Product Modification. Chembiochem. 2019 Sep 16;20(18):2402-2410. PMID: 31013547.
  • Halioua-Haubold CL, Jolly JK, Smith JA, Pinedo-Villanueva R, Brindley DA, MacLaren RE. Potential lifetime quality of life benefits of choroideremia gene therapy: projections from a clinically informed decision model. Eye (Lond). 2019 Aug;33(8):1215-1223. PMID: 31312000.
  • Muñoz DP, Yannone SM, Daemen A, Sun Y, Vakar-Lopez F, Kawahara M, Freund AM, Rodier F, Wu JD, Desprez PY, Raulet DH, Nelson PS, van ‘t Veer LJ, Campisi J, Coppé JP. Targetable mechanisms driving immunoevasion of persistent senescent cells link chemotherapy-resistant cancer to aging. JCI Insight. 2019 Jun 11;5. PMID: 31184599.
  • Moody KJ. A Translational Approach to Enzyme-Mediated Retinal Lipofuscin Removal for Atrophic Age-Related Macular Degeneration and Stargardt’s Disease (2019). Open Access Dissertations. 2261. Document via external site.
  • Ng KS, Smith JA, McAteer MP, Mead BE, Ware J, Jackson FO, Carter A, Ferreira L, Bure K, Rowley JA, Reeve B, Brindley DA, Karp JM. Bioprocess decision support tool for scalable manufacture of extracellular vesicles. Biotechnol Bioeng. 2019 Feb;116(2):307-319. PMID: 30063243.
  • Lam C, Meinert E, Alturkistani A, Carter AR, Karp J, Yang A, Brindley D, Cui Z. Decision Support Tools for Regenerative Medicine: Systematic Review. J Med Internet Res. 2018 Dec 19;20(12):e12448. PMID: 30567696.
  • Meinert E, Van Velthoven M, Brindley D, Alturkistani A, Foley K, Rees S, Wells G, de Pennington N. The Internet of Things in Health Care in Oxford: Protocol for Proof-of-Concept Projects. JMIR Res Protoc. 2018 Dec 4;7(12):e12077. PMID: 30514695.
  • Moody KJ, Tinklepaugh J, Obert E, Grohn K, DeRosa JR, Lumen E, Moyer BS, Campbell S, Wolfe AJ, Sleeper MB, Bianchi AH, Fisher C, Applegate J, Leary E, LeClair N, Wortel D, Doyle RP, Rohrer B, Blanden AR. Recombinant Manganese Peroxidase Reduces A2E Burden in Age-Related and Stargardt’s Macular Degeneration Models. Rejuvenation Res. 2018 Dec;21(6):560-571. PMID: 30516450.
  • Meinert E, Alturkistani A, Brindley D, Knight P, Wells G, de Pennington N. Weighing benefits and risks in aspects of security, privacy and adoption of technology in a value-based healthcare system. BMC Med Inform Decis Mak. 2018 Nov 13;18(1):100. PMID: 30424753.
  • Smith JA, Arshad Z, Trippe A, Collins GS, Brindley DA, Carr AJ. The Reporting Items for Patent Landscapes statement. Nat Biotechnol. 2018 Nov 9;36(11):1043-1047. PMID: 30412195.
  • Chow WY, Li R, Goldberga I, Reid DG, Rajan R, Clark J, Oschkinat H, Duer MJ, Hayward R, Shanahan CM. Essential but sparse collagen hydroxylysyl post-translational modifications detected by DNP NMR. Chem Commun (Camb). 2018 Nov 6;54(89):12570-12573. PubMed: 30299444.
  • Meinert E, Alturkistani A, Car J, Carter A, Wells G, Brindley D. Real-world evidence for postgraduate students and professionals in healthcare: protocol for the design of a blended massive open online course. BMJ Open. 2018 Oct 4;8(9):e025196. PMID: 30287615.
  • Alturkistani A, Majeed A, Car J, Brindley D, Wells G, Meinert E. Health information technology uses for primary prevention in preventive medicine: a scoping review protocol. BMJ Open. 2018 Oct 4;8(9):e023428. PMID: 30287611.
  • Galligan JJ, Wepy JA, Streeter MD, Kingsley PJ, Mitchener MM, Wauchope OR, Beavers WN, Rose KL, Wang T, Spiegel DA, Marnett LJ. Methylglyoxal-derived posttranslational arginine modifications are abundant histone marks. Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):9228-9233. PMID: 30150385.
  • Meinert E, Alturkistani A, Brindley D, Carter A, Wells G, Car J. Protocol for a mixed-methods evaluation of a massive open online course on real world evidence. BMJ Open. 2018 Aug 13;8(8):e025188. PMID: 30104321.
  • Osama T, Brindley D, Majeed A, Murray KA, Shah H, Toumazos M, Van Velthoven M, Car J, Wells G, Meinert E. Teaching the relationship between health and climate change: a systematic scoping review protocol. BMJ Open. 2018 May 20;8(5):e020330. PMID: 29780026.
  • Pettitt D, Arshad Z, Smith J, Stanic T, Holländer G, Brindley D. CAR-T Cells: A Systematic Review and Mixed Methods Analysis of the Clinical Trial Landscape. Mol Ther. 2018 Feb 7;26(2):342-353. PMID: 29248427.
  • Halioua-Haubold CL, Peyer JG, Smith JA, Arshad Z, Scholz M, Brindley DA, MacLaren RE. Regulatory Considerations for Gene Therapy Products in the US, EU, and Japan. Yale J Biol Med. 2017 Dec 19;90(4):683-693. PMID: 29259533.
  • Vijg J, Gravina S, Dong X. Intratissue DNA methylation heterogeneity in aging. Chapter 9 in Epigenetics of Aging and Longevity: Translational Epigenetics, Volume 4 (Moskalev A, Vaiserman AM, eds.). Academic Press (2017), pp 201-212.
  • Davies BM, Smith J, Rikabi S, Wartolowska K, Morrey M, French A, MacLaren R, Williams D, Bure K, Pinedo-Villanueva R, Mathur A, Birchall M, Snyder E, Atala A, Reeve B, Brindley D. A quantitative, multi-national and multi-stakeholder assessment of barriers to the adoption of cell therapies. J Tissue Eng. 2017 Aug 11;8:2041731417724413. PMID: 28835816.
  • Du W, Seah I, Bougazzoul O, Choi G, Meeth K, Bosenberg MW, Wakimoto H, Fisher D, Shah K. Stem cell-released oncolytic herpes simplex virus has therapeutic efficacy in brain metastatic melanomas. Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6157-E6165. doi: 10.1073/pnas.1700363114. Epub 2017 Jul 14. PMID: 28710334; PMCID: PMC5544283.
  • Yu B, Dong X, Gravina S, Kartal Ö, Schimmel T, Cohen J, Tortoriello D, Zody R, Hawkins RD, Vijg J. Genome-wide, Single-Cell DNA Methylomics Reveals Increased Non-CpG Methylation during Human Oocyte Maturation. Stem Cell Reports. 2017 Jul 11;9(1):397-407. PMID: 28648898.
  • Pettitt D, Arshad Z, Davies B, Smith J, French A, Cole D, Bure K, Dopson S, DiGiusto D, Karp J, Reeve B, Barker R, Holländer G, Brindley D. An assessment of the factors affecting the commercialization of cell-based therapeutics: a systematic review protocol. Syst Rev. 2017 Jun 26;6(1):120. PMID: 28651620.
  • Gaspar J, Mathieu J, Alvarez P. 2-Hydroxypropyl-beta-cyclodextrin (HPβCD) reduces age-related lipofuscin accumulation through a cholesterol-associated pathway. Sci Rep. 2017 May 19;7(1):2197. PMID: 28526856.
  • Liu Y, Conboy I. Unexpected evolutionarily conserved rapid effects of viral infection on oxytocin receptor and TGF-β/pSmad3. Skelet Muscle. 2017 May 15;7(1):7. PMID: 28506310.
  • Perrott KM, Wiley CD, Desprez PY, Campisi J. Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells. Geroscience. 2017 Apr;39(2):161-173. PubMed: 28378188.
  • Smith JA, Arshad Z, Thomas H, Carr AJ, Brindley DA. Evidence of insufficient quality of reporting in patent landscapes in the life sciences. Nat Biotechnol. 2017 Mar 7;35(3):210-214. PMID: 28267720.
  • Meretoja VV, Paul S, Planque SA. Hydrolysis and Dissolution of Amyloids by Catabodies. Methods Mol Biol. 2017;1643:111-134. PMID: 28667533.
  • Lee K, Conboy M, Park HM, Jiang F, Kim HJ, Dewitt MA, Mackley VA, Chang K, Rao A, Skinner C, Shobha T, Mehdipour M, Liu H, Huang WC, Lan F, Bray NL, Li S, Corn JE, Kataoka K, Doudna JA, Conboy I, Murthy N. Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair. Nat Biomed Eng. 2017;1:889-901. PMID: 29805845.
  • Rebo J, Mehdipour M, Gathwala R, Causey K, Liu Y, Conboy MJ, Conboy IM. A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood. Nat Commun. 2016 Nov 22;7:13363. PubMed: 27874859.
  • Gravina S, Dong X, Yu B, Vijg J. Single-cell genome-wide bisulfite sequencing uncovers extensive heterogeneity in the mouse liver methylome. Genome Biol. 2016 Jul 5;17(1):150. PubMed: 27380908.
  • Pettitt DA, Smith J, Meadows N, Arshad Z, Schuh A, DiGustio D, Bountra C, Holländer G, Barker R, Brindley DA. Regulatory barriers to the advancement of precision medicine. Expert Review of Precision Medicine and Drug Development 1: 319-329. Read on external site.
  • Pettitt DA, Smith J, Fuzerstenau-Sharp M, Holländer G, Predki P, Slade A, Jones P, Weed L, Bure K, Brindley DA. Emerging Platform Bioprocesses for Viral Vectors and Gene Therapies. BioProcess International 14(4)s. Read on external site.
  • Bure K, Ball A, Biagioni K, Mehta S, Choudhary R, Arshad Z, Pettitt DA, Holländer G, Al-Mossawi H, Faulstich F, Reeve B, Smith JA, Brindley DA. Automation of CAR-T Cell Adoptive Immunotherapy Bioprocessing. BioProcess International 14(4)s. Read on external site.
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  • Smith JA, Ng KS, Mead BE, Dopson S, Reeve B, Edwards J, Wood MJA, Carr AJ, Bure K, Karp JM, Brindley DA. Extracellular Vesicles: Commercial Potential As Byproducts of Cell Manufacturing for Research and Therapeutic Use. BioProcess International. 13(4). Read on external site.
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  • French A, Bravery C, Smith J, Chandra A, Archibald P, Gold JD, Artzi N, Kim HW, Barker RW, Meissner A, Wu JC, Knowles JC, Williams D, García-Cardeña G, Sipp D, Oh S, Loring JF, Rao MS, Reeve B, Wall I, Carr AJ, Bure K, Stacey G, Karp JM, Snyder EY, Brindley DA. Enabling consistency in pluripotent stem cell-derived products for research and development and clinical applications through material standards. Stem Cells Transl Med. 2015 Mar;4(3):217-23. PubMed: 25650438.
  • Silva M, Daheron L, Hurley H, Bure K, Barker R, Carr AJ, Williams D, Kim HW, French A, Coffey PJ, Cooper-White JJ, Reeve B, Rao M, Snyder EY, Ng KS, Mead BE, Smith JA, Karp JM, Brindley DA, Wall I. Generating iPSCs: Translating Cell Reprogramming Science into Scalable and Robust Biomanufacturing Strategies. Cell Stem Cell. 2015 Jan 8;16(1):13-7. PubMed: 25575079.
  • Smith JA, Naughton B, Kramm A, Smith G, Ohanjanyan A, De Simone M, Horne R, Brindley DA. European Union Falsified Medicines Directive: Requirements and Implications for Multi-Stakeholder Healthcare Delivery. Chapter 8 in Fundamentals of EU Regulatory Affairs, 7th Edition. Regulatory Affairs Professionals Society. Read on external site.
  • Smith JA, Bravery CA, Hollander G, Brindley DA. Regulating Regenerative Medicine: Cell Therapy, Gene Therapy and Tissue Engineering. Chapter 29 in Fundamentals of EU Regulatory Affairs, 7th Edition. Regulatory Affairs Professionals Society. Read on external site.
  • Smith JA, Reeve B, Carr A, Brindley DA. Regulating Regenerative Medicine: Cell Therapy, Gene Therapy and Tissue Engineering. Chapter 31 in Fundamentals of US Regulatory Affairs, 9th Edition. Regulatory Affairs Professionals Society. Read on external site.
  • Soland MA, Keyes LR, Bayne R, Moon J, Porada CD, St Jeor S, Almeida-Porada G. Perivascular stromal cells as a potential reservoir of human cytomegalovirus. Am J Transplant. 2014 Apr;14(4):820-30. doi: 10.1111/ajt.12642. Epub 2014 Mar 4 PubMed: 24592822.
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  • Davies BM, Rikabi SR, French A, Pinedo-Villanueva R, Morrey ME, Wartolowska K, Brindley DA. Quantitative assessment of barriers to the clinical development and adoption of cellular therapies: A pilot study. J Tissue Eng. 2014 Sep 19;5:2041731414551764. doi: 10.1177/2041731414551764. eCollection 2014. PubMed: 25383173.
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  • French A, Suh JY, Suh CY, Rubin L, Barker R, Bure K, Reeve B, Brindley DA. Global strategic partnerships in regenerative medicine. Trends Biotechnol. 2014 Sep;32(9):436-40. doi: 10.1016/j.tibtech.2014.05.007. PubMed: 25150363.
  • Boura JS, Vance M, Yin W, Madeira C, Lobato da Silva C, Porada CD, Almeida-Porada G. Evaluation of gene delivery strategies to efficiently overexpress functional HLA-G on human bone marrow stromal cells. Mol Ther Methods Clin Dev. 2014 Sep;2014(1). pii: 14041. PubMed: 25279386.
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  • Elabd C, Cousin W, Upadhyayula P, Chen RY, Chooljian MS, Li J, Kung S, Jiang KP, Conboy IM. Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration. Nat Commun. 2014 Jun 10;5:4082. doi: 10.1038/ncomms5082. PubMed: 24915299.
  • Wartolowska K, Judge A, Hopewell S, Collins GS, Dean BJ, Rombach I, Brindley D, Savulescu J, Beard DJ, Carr AJ. Use of placebo controls in the evaluation of surgery: systematic review. BMJ. 2014 May 21;348:g3253. doi: 10.1136/bmj.g3253. PubMed: 24850821.
  • Planque SA, Nishiyama Y, Hara M, Sonoda S, Murphy SK, Watanabe K, Mitsuda Y, Brown EL, Massey RJ, Primmer SR, O’Nuallain B, Paul S. Physiological IgM class catalytic antibodies selective for transthyretin amyloid. J Biol Chem. 2014 May 9;289(19):13243-58. doi: 10.1074/jbc.M114.557231. PubMed: 24648510.
  • Phay M, Blinder V, Macy S, Greene MJ, Wooliver DC, Liu W, Planas A, Walsh DM, Connors LH, Primmer SR, Planque SA, Paul S, O’Nuallain B. Transthyretin aggregate-specific antibodies recognize cryptic epitopes on patient-derived amyloid fibrils. Rejuvenation Res. 2014 Apr;17(2):97-104. doi: 10.1089/rej.2013.1524. PubMed: 24164623.
  • Akman K, Haaf T, Gravina S, Vijg J, Tresch A. Genome-wide quantitative analysis of DNA methylation from bisulfite sequencing data. Bioinformatics. 2014 Jul 1;30(13):1933-4. doi: 10.1093/bioinformatics/btu142. Epub 2014 Mar 10. PubMed: 24618468.
  • Brindley DA, French AL, Baptista R, Timmins N, Adams T, Wall I, Bure K. Cell Therapy Bioprocessing Technologies and Indicators of Technological Convergence. BioProcess International 12(3)s (March 2014). Read on external site.
  • Chen Y, Ma X, Zhang M, Wang X, Wang C, Wang H, Guo P, Yuan W, Rudolph KL, Zhan Q, Ju Z. Gadd45a regulates hematopoietic stem cell stress responses in mice. Blood. 2014 Feb 6;123(6):851-62. doi: 10.1182/blood-2013-05-504084. PubMed: 24371210.
  • French AL, Bure K, Brindley DA. CASMI TSCC Launch Event, Paris, France, July 2013: An Assessment of the Key Barriers to the Commercialization and Clinical Adoption of Pluripotent Stem Cell Therapies. Rejuvenation Res. February 2014, 17(1): 84-88. doi:10.1089/rej.2014.1545. PubMed: 24392658.
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  • Rehki R, Wall I, French A, Bure K, Carr AJ, Brindley DA. Cell Therapy Biomanufacturing Risk Management. In: Cell Therapy Translation (D. Williams and D. Scadden, eds.), StemBook, 2014.
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  • Brindley DA, French A, Suh J, Roberts M, Davies B, Pinedo-Villanueva R, Wartolowska K, Rooke K, Kramm A, Judge A, Morrey M, Chandra A, Hurley H, Grover L, Bingham I, Siegel B, Rattley MS, Buckler RL, McKeon D, Krumholz K, Hook L, May M, Rikabi S, Pigott R, Morys M, Sabokbar A, Titus E, Laabi Y, Lemaitre G, Zahkia R, Sipp D, Horne R, Bravery C, Williams D, Wall I, Snyder EY, Karp JM, Barker RW, Bure K, Carr AJ, Reeve B. The implementation of novel collaborative structures for the identification and resolution of barriers to pluripotent stem cell translation. Stem Cells Dev 2013;22 Suppl 1:63-72. PubMed: 24304079.
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  • Brindley DA, Wall IB. Commercial Manufacture of Cell Therapies. In: Standardization in Cell and Tissue Engineering: Methods and Protocols (V. Salih, ed.) Woodhead Publishing, 2012, pp. 212-240. Read on external site.
  • Barker RW, Brindley DA, Schuh A. Establish good genomic practice to guide medicine forward. Nat Med. 2013 May;19(5):530. doi: 10.1038/nm0513-530. PubMed: 23652098.
  • Davalos AR, Kawahara M, Malhotra GK, Schaum N, Huang J, Ved U, Beausejour CM, Coppe JP, Rodier F, Campisi J. p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes. J Cell Biol 2013;201(4):613-29. PubMed: 23649808.
  • French A, Buckler RL, Brindley DA. Commercialization of regenerative medicine: learning from spin-outs. Rejuvenation Res 2013;16(2):164-70. PubMed: 23470045.
  • Brindley DA, Wall IB, Bure K. Automation of Cell Therapy Biomanufacturing: Minimizing Regulatory Risks and Maximising Return on Investment. Bioprocess International, Supplement; vol. 11, No. S3, March 2013, pp. 18–25.
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  • Kim T, Spiegel DA. The unique reactivity of N-phenacyl-derived thiazolium salts toward alpha-dicarbonyl compounds. Rejuvenation Res. 2013 Feb;16(1):43-50. doi: 10.1089/rej.2012.1370. PubMed: 23186164.
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  • Culme-Seymour EJ, Davie NL, Brindley DA, Edwards-Parton S, Mason C. A decade of cell therapy clinical trials (2000–2010). Regen Med. 2012 Jul;7(4):455-62. PubMed: 22817619.
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  • Brindley DA, Davie NL, Sahlman WA, Bonfiglio GA, Culme-Seymour EJ, Reeve BC, Mason C. Promising growth and investment in the cell therapy industry during the first quarter of 2012. Cell Stem Cell. 2012 May 4;10(5):492-6. PubMed: 22560072.
  • Brindley DA, Mason C. The Commercialisation of Cell Therapies. In: Progenitor and stem cell technologies and therapies: Principles and Issues (Vol 1). Woodhead Publishing (2012). Read on external site.
  • Davie ND, Brindley DA, Culme-Seymour EJ, Mason C. Streamlining Cell Therapy Manufacturing: From Clinical to Commercial Scale. BioProcess International. 10(3):24-29. Read on external site.
  • Brindley D, Reeve B, Mason C. Pharmaceutical industry: Investors unfazed by drug-patent expiry. Nature. 2012 Jan 18;481(7381):265. PubMed: 22258594.
  • Brindley DA, Davie NL, Culme-Seymour EJ, Mason C, Smith DW, Rowley JA. Peak serum: implications of serum supply for cell therapy manufacturing. Regen Med. 2012 Jan;7(1):7-13. doi: 10.2217/rme.11.112. PubMed: 22168489.
  • Brindley D, Mason C. Human embryonic stem cell therapy in the post-Geron era. Regen Med. 2012 Jan;7(1):17-8. doi: 10.2217/rme.11.115. PubMed: 22168491.
  • Brindley DA, Reeve BC, Sahlman WA, Bonfiglio GA, Davie NL, Culme-Seymour EJ, Mason C. The impact of market volatility on the cell therapy industry. Cell Stem Cell. 2011 Nov 4;9(5):397-401. PubMed: 22056137.
  • Brindley D, Moorthy K, Lee JH, Mason C, Kim HW, Wall I. Bioprocess forces and their impact on cell behavior: implications for bone regeneration therapy. J Tissue Eng. 2011;2011:620247. PubMed: 21904661.
  • Mason C, Brindley DA, Culme-Seymour EJ, Davie NL. Cell therapy industry: billion dollar global business with unlimited potential. Regen Med. 2011 May;6(3):265-72. PubMed: 21548728.
  • Wu Y, Zhou J, Fishkin N, Rittmann BE, Sparrow JR. Enzymatic degradation of A2E, a retinal pigment epithelial lipofuscin bisretinoid. J Am Chem Soc. 2011 Feb 2;133(4):849-57. doi: 10.1021/ja107195u. PubMed: 21166406.
  • Peto MV. Aluminium and iron in humans: bioaccumulation, pathology, and removal. Rejuvenation Res 2010 Oct;13(5):589-98. PubMed: 21142669.
  • Rebo J, Causey K, Zealley B, Webb T, Hamalainen M, Cook B, Schloendorn J. Whole-animal senescent cytotoxic T cell removal using antibodies linked to magnetic nanoparticles. Rejuvenation Res. 2010 Apr-Jun;13(2-3):298-300. doi: 10.1089/rej.2009.0964. PubMed: 20426617.
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  • Mathieu JM, Mohn WW, Eltis LD, LeBlanc JC, Stewart GR, Dresen C, Okamoto K, Alvarez PJ. 7-ketocholesterol catabolism by Rhodococcus jostii RHA1. Appl Environ Microbiol. 2010 Jan;76(1):352-5. doi: 10.1128/AEM.02538-09. PubMed: 19880645.

In 2009 and earlier, research into SENS was supported by the Methuselah Foundation.

  • Schloendorn J, Webb T, Kemmish K, Hamalainen M, Jackemeyer D, Jiang L, Mathieu J, Rebo J, Sankman J, Sherman L, Tontson L, Qureshi A, Alvarez P, Rittmann B. Medical bioremediation: a concept moving toward reality. Rejuvenation Res. 2009 Dec;12(6):411-9. doi: 10.1089/rej.2009.0917. PubMed: 20041735.
  • Brindley DA, Davie N. Regenerative Medicine Through a Crisis: Social Perception and the Financial Reality. Rejuvenation Research 2009, 12(6): 455-461. PubMed: 20041739.
  • Mathieu JM, Schloendorn J, Rittmann BE, Alvarez PJ. Medical bioremediation of age-related diseases. Microb Cell Fact. 2009 Apr 9;8:21. doi: 10.1186/1475-2859-8-21. PubMed: 19358742.
  • Sjöberg JS, Bulterijs S. Characteristics, formation, and pathophysiology of glucosepane: a major protein cross-link. Rejuvenation Res 2009;12(2):137-48. PubMed: 19415980.
  • Ellouze S, Augustin S, Bouaita A, Bonnet C, Simonutti M, Forster V, Picaud S, Sahel JA, Corral-Debrinski M. Optimized allotopic expression of the human mitochondrial ND4 prevents blindness in a rat model of mitochondrial dysfunction. Am J Hum Genet. 2008 Sep;83(3):373-87. doi: 10.1016/j.ajhg.2008.08.013. PubMed: 18771762.
  • Mathieu J, Schloendorn J, Rittmann BE, Alvarez PJ. Microbial degradation of 7-ketocholesterol. Biodegradation. 2008;19(6):807-13. PubMed: 18344006.
  • Rittmann BE, Schloendorn J. Engineering away lysosomal junk: medical bioremediation. Rejuvenation Res 2007;10(3):359-365. PubMed: 17708688.
  • Bonnet C, Kaltimbacher V, Ellouze S, Augustin S, Bénit P, Forster V, Rustin P, Sahel JA, Corral-Debrinski M. Allotopic mRNA localization to the mitochondrial surface rescues respiratory chain defects in fibroblasts harboring mitochondrial DNA mutations affecting complex I or V subunits. Rejuvenation Res 2007;10(2):127-144. PubMed: 17518546.

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