Category: News

Scientists have discovered that a cytotoxic subtype of CD4 T cells, which is enriched in old people, helps control cellular senescence. This hints at a new type of anti-senescence strategy but also suggests that an immune system can be “overly youthful.” When generals become fighters CD4 T cells usually behave as “generals”, directing immune attacks...

In a preprint published in bioRxiv, Prof. Vadim Gladyshev and a team of researchers have used an artificial intelligence-based system to discover a wide variety of potential interventions, including a drug that significantly improves biomarkers of frailty in mice. Repurposing previous data Previous research efforts have created a massive dataset in the form of the...

A recent study investigated the impact of two amino acids, phenylalanine and tyrosine, on lifespan using UK Biobank data. The researchers reported an association between tyrosine and shorter lifespan, with sex-specific differences. The results for phenylalanine were more inconsistent [1]. One by one Model animal research has shown that protein restriction can extend lifespan. However,...

In a recent study, scientists have demonstrated that lysosomal dysfunction actively decreases the potency of hematopoietic stem cells. Calming lysosomes reversed this process, opening avenues for new treatments [1]. Few and far between Hematopoietic stem cells (HSCs) are rare and precious: they produce blood progenitor cells, which, in turn, produce all differentiated blood cells. With...

Scientists have created “nanoflowers” that nudge donor cells to produce more mitochondria, which can then be transferred to recipient cells to boost their mitochondrial function [1]. Mitochondrial transfer is difficult to improve Energy is required for life, and most energy in our cells is produced by mitochondria. When these organelles start to falter, it's a...

George Church, a Harvard professor and a famed geroscientist, is also known as a serial entrepreneur who has co-founded dozens of biotech companies. While Church maintains that he’s involved in them all, one company has been seeing an unusual amount of his attention: Lila Sciences, where he assumed the role of Chief Scientist. On its...